Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 8/20 | 0.61 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.61 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.61 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | CDK1 | P06493 | 1/20 | 0.61 |
| ▸ | CDK4 | P11802 | 1/20 | 0.61 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.61 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.61 |
| ▸ | CCND1 | P24385 | 1/20 | 0.61 |
| ▸ | CDK7 | P50613 | 1/20 | 0.61 |
| ▸ | CDK9 | P50750 | 1/20 | 0.61 |
| ▸ | CCNH | P51946 | 1/20 | 0.61 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.61 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | ATG4B | Q9Y4P1 | 3/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6288010 | 0.88 | CDK2 (0.69) | CDK2CCNE1CDK5CCNT1ALDH1A1 | |
| SCHEMBL6283555 | 0.78 | ATG4B (0.62) | CDK2CCNE1CDK5CCNT1ALDH1A1 | |
| SCHEMBL6286739 | 0.77 | ATG4B (0.64) | CDK2CCNE1CDK5CCNT1ALDH1A1 | |
| SCHEMBL6286130 | 0.77 | ATG4B (0.63) | CDK2CCNE1CDK5CCNT1ALDH1A1 | |
| SCHEMBL6285422 | 0.77 | ATG4B (0.63) | CDK2CCNE1CDK5CCNT1ALDH1A1 | |
| SCHEMBL1535301 | 0.76 | CCNE1 (1.00) | CDK2CCNE1CDK5CCNT1ALDH1A1 | |
| SCHEMBL6285981 | 0.76 | CDK2 (0.64) | CDK2CCNE1CDK5CCNT1ALDH1A1 | |
| SCHEMBL6278561 | 0.76 | CDK2 (0.64) | CDK2CCNE1CDK5CCNT1ALDH1A1 | |
| SCHEMBL6284074 | 0.76 | CDK2 (1.00) | CDK2CCNE1CDK5CCNT1ALDH1A1 | |
| SCHEMBL6287944 | 0.76 | ATG4B (0.66) | CDK2CCNE1CDK5CCNT1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6863647-B2 | 2-Ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2005-03-08 | — | — | US | disclosed |