Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | GLS | O94925 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31035955 | 0.94 | TDP1 (0.56) | HSD17B10GAAMAPK1KMT2AMEN1 | |
| SCHEMBL29263678 | 0.94 | TDP1 (0.56) | HSD17B10GAAMAPK1KMT2AMEN1 | |
| SCHEMBL4651676 | 0.83 | HSD17B10 (0.82) | HSD17B10KMT2AMEN1ALDH1A1PKM | |
| SCHEMBL245402 | 0.81 | MEN1 (0.68) | HSD17B10GAAMAPK1KMT2AMEN1 | |
| SCHEMBL29263618 | 0.78 | HSD17B10 (0.77) | HSD17B10KMT2AMEN1ALDH1A1PKM | |
| SCHEMBL4651550 | 0.78 | KMT2A (0.63) | GAAMAPK1KMT2AALDH1A1TDP1 | |
| SCHEMBL12733795 | 0.77 | HSD17B10 (0.71) | HSD17B10KMT2AMEN1ALDH1A1PKM | |
| SCHEMBL6789096 | 0.77 | TDP1 (0.55) | HSD17B10ALDH1A1PKMTDP1L3MBTL1 | |
| SCHEMBL7555289 | 0.75 | MEN1 (0.57) | HSD17B10KMT2AMEN1TDP1L3MBTL1 | |
| SCHEMBL1677739 | 0.75 | TDP1 (0.66) | ALDH1A1PKMTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6953785-B2 | Estra-1,3,5(10)-triene derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2005-10-11 | — | — | US | disclosed |
| US-20030216362-A1 | Estra-1,3,5 (10)-triene derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2003-11-20 | — | — | US | disclosed |
| EP-1284272-A1 | ESTRA-1,3,5(10)-TRIENE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2003-02-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030216362-A1 | Estra-1,3,5 (10)-triene derivatives | STS, SULT1E1, SULT1A1 | HSD17B10 36/4885GAA 1133/4885MAPK1 3245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.