Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.55 |
| ▸ | PDE1A | P54750 | 3/20 | 0.55 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.55 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.55 |
| ▸ | BRD4 | O60885 | 2/20 | 0.52 |
| ▸ | BRD2 | P25440 | 2/20 | 0.52 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.42 |
| ▸ | PI4KA | P42356 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6288624 | 0.91 | PDE5A (0.58) | PDE5APDE1APDE1BPDE1CBRD4 | |
| SCHEMBL6291835 | 0.83 | PDE5A (0.59) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL6288422 | 0.79 | BRD4 (0.47) | PDE5APDE1APDE1BPDE1CBRD4 | |
| SCHEMBL6288397 | 0.79 | BRD4 (0.47) | BRD4BRD2BRD3KMT2API4KB | |
| SCHEMBL6291791 | 0.77 | PDE5A (0.59) | PDE5APDE1APDE1BPDE1CALDH1A1 | |
| SCHEMBL6291403 | 0.77 | PDE5A (0.55) | PDE5APDE1APDE1BPDE1CBRD4 | |
| Oxirane SCHEMBL7601429 | 0.76 | PDE5A (0.64) | PDE5APDE1APDE1BPDE1CBRD4 | |
| SCHEMBL5901825 | 0.75 | PDE5A (0.65) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL6291382 | 0.73 | ALDH1A1 (0.45) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL6286872 | 0.72 | BRD4 (0.43) | PDE5ABRD4BRD2BRD3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6936609-B2 | Imidazotriazines for use as phosphodiesterase inhibitors | BAYER HEALTHCARE AG (DE) | 2005-08-30 | — | — | US | disclosed |
| US-20040249148-A1 | Imidazotriazines for use as phosphodiesterase inhibitors | BAYER HEALTHCARE AG (DE) | 2004-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040249148-A1 | Imidazotriazines for use as phosphodiesterase inhibitors | PDE3A, PDE2A, PDE4A | PDE5A 4/4885PDE1A 8/4885PDE1B 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.