Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.53 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.45 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7724890 | 0.82 | EPHX2 (0.57) | EPHX2HPGDKMT2AEPHX1KEAP1 | |
| SCHEMBL15680573 | 0.82 | KEAP1 (0.66) | EPHX2HPGDKMT2AEPHX1KEAP1 | |
| SCHEMBL23016392 | 0.81 | KEAP1 (0.57) | EPHX2HPGDKMT2AEPHX1KEAP1 | |
| SCHEMBL8848512 | 0.81 | EPHX2 (0.55) | EPHX2HPGDKMT2AEPHX1KEAP1 | |
| SCHEMBL24340632 | 0.80 | KEAP1 (0.60) | EPHX2HPGDKMT2AEPHX1KEAP1 | |
| SCHEMBL13527977 | 0.80 | EPHX2 (0.54) | EPHX2HPGDKMT2AEPHX1KEAP1 | |
| SCHEMBL7452577 | 0.79 | EPHX2 (0.54) | EPHX2HPGDKMT2AEPHX1KEAP1 | |
| SCHEMBL16326257 | 0.79 | KEAP1 (0.55) | EPHX2HPGDKMT2AEPHX1KEAP1 | |
| SCHEMBL17771351 | 0.78 | EPHX2 (0.53) | EPHX2HPGDKMT2AEPHX1KEAP1 | |
| SCHEMBL6360164 | 0.78 | EPHX2 (0.53) | EPHX2HPGDKMT2AEPHX1KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0986384-B1 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIV PITTSBURGH (US) | 2012-02-22 | — | — | EP | disclosed |
| EP-0986384-B1 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIV PITTSBURGH (US) | 2012-02-22 | — | — | EP | disclosed |