Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL3 | Q96RI0 | 4/20 | 0.49 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.45 |
| ▸ | FEN1 | P39748 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KLK7 | P49862 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6544282 | 0.87 | ALOX5AP (0.52) | F2RL3ALOX5APFEN1MEN1KMT2A | |
| SCHEMBL5152041 | 0.82 | ALOX5AP (0.46) | F2RL3ALOX5APFEN1HSD11B1MEN1 | |
| SCHEMBL2200755 | 0.81 | CHRNB4 (0.58) | F2RL3ALOX5APFEN1MEN1KMT2A | |
| SCHEMBL1240615 | 0.81 | F2RL3 (0.47) | F2RL3ALOX5APFEN1MEN1KMT2A | |
| SCHEMBL1241581 | 0.81 | F2RL3 (0.47) | F2RL3ALOX5APFEN1MEN1KMT2A | |
| SCHEMBL5155609 | 0.81 | DPP4 (0.49) | F2RL3ALOX5APFEN1GPR119 | |
| SCHEMBL2539185 | 0.81 | F2RL3 (0.50) | F2RL3ALOX5APFEN1 | |
| SCHEMBL7997720 | 0.81 | F2RL3 (0.50) | F2RL3ALOX5APFEN1 | |
| SCHEMBL3113607 | 0.81 | DPP4 (0.52) | F2RL3ALOX5APFEN1MEN1KMT2A | |
| SCHEMBL2200803 | 0.81 | ALOX5AP (0.50) | F2RL3ALOX5APFEN1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867200-B1 | (Hetero)aryl-bicyclic heteroaryl derivatives, their preparation and their use as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2005-03-15 | — | — | US | disclosed |
| EP-1140859-A2 | (HETERO)ARYL-BICYCLIC HETEROARYL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035886-A2 | (HETERO)ARYL-BICYCLIC HETEROARYL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-06-22 | — | — | WO | disclosed |