Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.68 |
| ▸ | GAA | P10253 | 2/20 | 0.68 |
| ▸ | ATM | Q13315 | 1/20 | 0.66 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.64 |
| ▸ | CNR1 | P21554 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA5A | P35218 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10585628 | 0.86 | TRPV1 (0.83) | HPGDGAAATMTRPV1CNR1 | |
| SCHEMBL320807 | 0.84 | HPGD (0.68) | HPGDGAAATMTRPV1CNR1 | |
| SCHEMBL4153733 | 0.84 | HPGD (0.79) | HPGDGAAATMTRPV1CNR1 | |
| SCHEMBL5878927 | 0.84 | HPGD (0.68) | HPGDGAAATMTRPV1CNR1 | |
| SCHEMBL3688416 | 0.82 | HPGD (0.66) | HPGDGAAATMTRPV1CNR1 | |
| SCHEMBL5181766 | 0.82 | HPGD (0.66) | HPGDGAAATMTRPV1CNR1 | |
| SCHEMBL4528693 | 0.82 | HPGD (0.66) | HPGDGAAATMTRPV1CNR1 | |
| SCHEMBL1927410 | 0.82 | HPGD (0.66) | HPGDGAAATMTRPV1CNR1 | |
| SCHEMBL2967921 | 0.82 | HPGD (0.66) | HPGDGAAATMTRPV1CNR1 | |
| SCHEMBL11114018 | 0.82 | HPGD (0.66) | HPGDGAAATMTRPV1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867200-B1 | (Hetero)aryl-bicyclic heteroaryl derivatives, their preparation and their use as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2005-03-15 | — | — | US | disclosed |