Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.70 |
| ▸ | NPC1 | O15118 | 3/20 | 0.70 |
| ▸ | RAB9A | P51151 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | HTT | P42858 | 1/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6289034 | 0.87 | HPGD (0.58) | HPGDNPC1RAB9AKMT2AHTT | |
| SCHEMBL14670856 | 0.87 | HPGD (0.70) | HPGDNPC1RAB9AKMT2AHTT | |
| SCHEMBL6290075 | 0.87 | HPGD (0.70) | HPGDNPC1RAB9AKMT2AHTT | |
| SCHEMBL25189340 | 0.85 | HPGD (0.68) | HPGDNPC1RAB9AKMT2AHTT | |
| SCHEMBL31248400 | 0.85 | HPGD (0.68) | HPGDNPC1RAB9AKMT2AHTT | |
| SCHEMBL31512540 | 0.84 | HPGD (0.67) | HPGDNPC1RAB9AKMT2AHTT | |
| SCHEMBL27377952 | 0.84 | HPGD (0.68) | HPGDNPC1RAB9AKMT2AHTT | |
| SCHEMBL17335848 | 0.84 | HPGD (0.68) | HPGDNPC1RAB9AKMT2AHTT | |
| SCHEMBL885000 | 0.83 | MTNR1A (0.71) | HPGDNPC1RAB9AKMT2AHTT | |
| SCHEMBL2938380 | 0.83 | KMT2A (0.69) | HPGDNPC1RAB9AKMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867200-B1 | (Hetero)aryl-bicyclic heteroaryl derivatives, their preparation and their use as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2005-03-15 | — | — | US | disclosed |