Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 9/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 9/20 | 0.52 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NQO2 | P16083 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6290892 | 0.92 | AKR1C2 (0.46) | MTNR1AMTNR1BAKR1C2HDAC1MEN1 | |
| SCHEMBL6286858 | 0.91 | MEN1 (0.42) | MTNR1AMTNR1BAKR1C2HDAC1MEN1 | |
| SCHEMBL6286746 | 0.91 | MEN1 (0.42) | MTNR1AMTNR1BAKR1C2HDAC1MEN1 | |
| Hydrochloric Acid SCHEMBL6282711 | 0.90 | AKR1C2 (0.47) | MTNR1AMTNR1BAKR1C2HDAC1MEN1 | |
| Hydrochloric Acid SCHEMBL7039786 | 0.90 | AKR1C2 (0.47) | MTNR1AMTNR1BAKR1C2HDAC1MEN1 | |
| SCHEMBL7030590 | 0.87 | MTNR1A (0.41) | MTNR1AMTNR1BHDAC1MEN1MAPT | |
| SCHEMBL6287524 | 0.86 | AKR1C2 (0.48) | MTNR1AMTNR1BAKR1C2HDAC1MEN1 | |
| SCHEMBL7034720 | 0.86 | AKR1C2 (0.52) | MTNR1AMTNR1BAKR1C2HDAC1MEN1 | |
| Trifluoroacetic Acid SCHEMBL6290277 | 0.85 | AKR1C2 (0.46) | MTNR1AMTNR1BAKR1C2HDAC1MEN1 | |
| SCHEMBL6284089 | 0.85 | AKR1C2 (0.50) | MTNR1AMTNR1BAKR1C2HDAC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6887890-B2 | Compounds exhibiting thrombopoietin-like activities | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-05-03 | — | — | US | disclosed |
| US-20030162724-A1 | Compounds exhibiting thrombopoietin-like activities | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-08-28 | — | — | US | disclosed |
| EP-1291341-A1 | COMPOUNDS EXHIBITING THROMBOPOIETIN-LIKE ACTIVITIES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030162724-A1 | Compounds exhibiting thrombopoietin-like activities | MPL, THPO, TEK | MTNR1A 270/4885MTNR1B 175/4885AKR1C2 2816/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.