Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | AGXT | P21549 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TK1 | P04183 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6941005 | 0.89 | TSHR (0.67) | TSHRALOX5IDO1AGXTALDH1A1 | |
| SCHEMBL4079622 | 0.82 | TSHR (0.56) | TSHRALOX5IDO1TDP1L3MBTL1 | |
| SCHEMBL4069935 | 0.79 | TSHR (0.58) | TSHRALOX5IDO1HTTAGXT | |
| SCHEMBL28764214 | 0.78 | TSHR (0.56) | TSHRALOX5IDO1TDP1L3MBTL1 | |
| SCHEMBL15475317 | 0.78 | TSHR (0.56) | TSHRALOX5IDO1HTTTDP1 | |
| SCHEMBL854566 | 0.77 | MAOB (0.48) | TSHRIDO1TDP1ALDH1A1CA1 | |
| SCHEMBL798003 | 0.77 | TSHR (0.61) | TSHRALOX5IDO1HTTTDP1 | |
| SCHEMBL1524101 | 0.76 | TSHR (0.67) | TSHRALOX5IDO1HTTAGXT | |
| SCHEMBL1524098 | 0.76 | TSHR (0.67) | TSHRALOX5IDO1HTTAGXT | |
| SCHEMBL1524411 | 0.76 | TSHR (0.67) | TSHRALOX5IDO1HTTAGXT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6846828-B2 | Aminopyrimidine and aminopyridine anti-inflammation agents | ROCHE PALO ALTO LLC (US) | 2005-01-25 | — | — | US | disclosed |