SCHEMBL629259

SCHEMBL629259

CO[Si](C)(CNc1ccccc1)OC.CO[Si](CNc1ccccc1)(OC)OC

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.38
ALDH1A1 P00352 3/20 0.36
KCNH3 Q9ULD8 2/20 0.35
TAAR1 Q96RJ0 1/20 0.34
GRM5 P41594 1/20 0.34
MAOA P21397 1/20 0.33
MAOB P27338 1/20 0.33
KMT2A Q03164 4/20 0.33
MEN1 O00255 3/20 0.33
RAB9A P51151 2/20 0.33
LMNA P02545 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.32
NPC1 O15118 1/20 0.32
TSHR P16473 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2C9 P11712 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL57449 0.93 MAPT (0.42) MAPTALDH1A1KCNH3TAAR1MAOA
Benzene SCHEMBL28332770 0.91 MAPT (0.43) MAPTALDH1A1KCNH3TAAR1GRM5
SCHEMBL114143 0.91 MAPT (0.43) MAPTALDH1A1KCNH3TAAR1GRM5
SCHEMBL788211 0.85 MAPT (0.40) MAPTALDH1A1KCNH3TAAR1GRM5
O-Xylene SCHEMBL27577493 0.84 MAPT (0.39) MAPTALDH1A1KCNH3TAAR1GRM5
SCHEMBL16792581 0.81 HDAC3 (0.33) MAPTALDH1A1MAOA
SCHEMBL28383132 0.79 MAPT (0.38) MAPTALDH1A1KCNH3TAAR1GRM5
SCHEMBL29008630 0.77 MAPT (0.37) MAPTALDH1A1KCNH3TAAR1GRM5
SCHEMBL978043 0.77 MAPT (0.42) MAPTALDH1A1KCNH3TAAR1MAOA
SCHEMBL28937413 0.76 MAPT (0.39) MAPTALDH1A1KCNH3TAAR1GRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2145909-B1 Method for producing blocked alcohols SIKA TECHNOLOGY AG (CH) 2012-02-22 EP disclosed
EP-2145909-A1 Method for producing blocked alcohols Sika Technology AG (CH) 2010-01-20 EP disclosed