SCHEMBL6293446

SCHEMBL6293446

[c]1cccc(CCc2cccnc2)c1

nearest known ligand 0.53

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 2/20 0.53
CYP1A2 P05177 2/20 0.50
CYP2D6 P10635 2/20 0.50
CYP2A6 P11509 1/20 0.50
HRH4 Q9H3N8 2/20 0.49
HRH3 Q9Y5N1 2/20 0.49
TDP1 Q9NUW8 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
HRH1 P35367 2/20 0.47
TBXAS1 P24557 2/20 0.44
CHRNB2 P17787 2/20 0.43
CHRNA4 P43681 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10492340 0.85 CYP11B1 (0.46) CHRNA7CYP1A2CYP2D6CYP2A6HRH4
SCHEMBL724866 0.82 CHRNA7 (0.74) CHRNA7CYP1A2CYP2D6CYP2A6HRH4
SCHEMBL29485692 0.82 CHRNA7 (0.74) CHRNA7CYP1A2CYP2D6CYP2A6HRH4
SCHEMBL10492284 0.81 CHRNA7 (0.57) CHRNA7CYP1A2CYP2D6CYP2A6HRH4
SCHEMBL1041978 0.81 CYP1A2 (0.70) CYP1A2CYP2D6TDP1
SCHEMBL3170078 0.79 CHRNA7 (0.44) CHRNA7CYP1A2CYP2D6CYP2A6TDP1
SCHEMBL3154751 0.78 CYP2D6 (0.51) CHRNA7CYP1A2CYP2D6CYP2A6HRH4
SCHEMBL28057954 0.76 CHRNA7 (0.52) CHRNA7CYP1A2CYP2D6CYP2A6HRH4
SCHEMBL10452373 0.76 CHRNA7 (0.65) CHRNA7CYP1A2CYP2D6CYP2A6HRH4
SCHEMBL8700016 0.76 CYP1A2 (0.66) CHRNA7CYP1A2CYP2D6CYP2A6HRH4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6979693-B2 Pyrazole derivatives-p38 MAP kinase inhibitors SYNTEX (U.S.A.) LLC (US) 2005-12-27 US disclosed
CN-1147476-C Pyrazole derivatives as P-38 MAP kinase inhibitors - 2004-04-28 CN disclosed
US-6444696-B1 1-ARYL OR HETEROARYL SUBSTITUTED 5-AMINO-4 CARBONYLPYRAZOLE DERIVATIVES; ANTIINFLAMMATORY AGENTS SYNTEX (U.S.A.) LLC 2002-09-03 US disclosed
US-6376527-B1 ANTIINFLAMMATORY AGENTS; AUTOIMMUNE DISEASES SYNTEX (U.S.A.) LLC 2002-04-23 US disclosed
US-6316466-B1 Pyrazole derivatives P-38 MAP kinase inhibitors SYNTEX (U.S.A.) LLC 2001-11-13 US disclosed
CN-1300282-A Pyrazole derivatives as P-38 MAP kinase inhibitors HOFFMANN LA ROCHE (CH) 2001-06-20 CN disclosed