Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 14/20 | 0.80 |
| ▸ | F10 | P00742 | 14/20 | 0.80 |
| ▸ | PLAU | P00749 | 12/20 | 0.80 |
| ▸ | PRSS1 | P07477 | 12/20 | 0.80 |
| ▸ | PLG | P00747 | 11/20 | 0.80 |
| ▸ | PLAT | P00750 | 10/20 | 0.80 |
| ▸ | HPN | P05981 | 1/20 | 0.66 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.66 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.66 |
| ▸ | F7 | P08709 | 3/20 | 0.64 |
| ▸ | F9 | P00740 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6289543 | 0.82 | F2 (0.76) | F2F10PLAUPRSS1PLG | |
| SCHEMBL14599555 | 0.82 | PLAU (0.77) | F2F10PLAUPRSS1PLG | |
| SCHEMBL14519390 | 0.81 | PLAU (0.86) | F2F10PLAUPRSS1PLG | |
| SCHEMBL14355116 | 0.80 | PLAU (0.83) | F2F10PLAUPRSS1PLG | |
| SCHEMBL5517426 | 0.80 | PLAU (0.83) | F2F10PLAUPRSS1PLG | |
| SCHEMBL14259709 | 0.80 | F2 (0.71) | F2F10PLAUPRSS1PLG | |
| SCHEMBL4315225 | 0.80 | F2 (1.00) | F2F10PLAUPRSS1PLG | |
| SCHEMBL29367440 | 0.80 | PLAU (0.73) | F2F10PLAUPRSS1PLG | |
| SCHEMBL24312880 | 0.78 | PLAU (0.81) | F2F10PLAUPRSS1PLG | |
| SCHEMBL5399365 | 0.77 | PLAU (0.66) | F2F10PLAUPRSS1PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867200-B1 | (Hetero)aryl-bicyclic heteroaryl derivatives, their preparation and their use as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2005-03-15 | — | — | US | disclosed |
| EP-1140859-A2 | (HETERO)ARYL-BICYCLIC HETEROARYL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035886-A2 | (HETERO)ARYL-BICYCLIC HETEROARYL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-06-22 | — | — | WO | disclosed |