Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 20/20 | 0.56 |
| ▸ | GABRB3 | P28472 | 20/20 | 0.56 |
| ▸ | GABRA3 | P34903 | 20/20 | 0.56 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.56 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.56 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6293000 | 0.85 | GABRG2 (0.58) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL2652749 | 0.81 | GABRG2 (0.82) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL6292561 | 0.80 | GABRG2 (0.56) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL5230753 | 0.76 | GABRG2 (0.58) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL5230593 | 0.75 | GABRG2 (0.66) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL6294094 | 0.73 | GABRG2 (0.70) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL2655126 | 0.73 | GABRG2 (0.75) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL2655013 | 0.73 | GABRG2 (0.80) | GABRG2GABRB3GABRA3GABRA1 | |
| SCHEMBL6292919 | 0.73 | GABRG2 (0.57) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL2659079 | 0.73 | GABRG2 (0.58) | GABRG2GABRB3GABRA3GABRA1GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6872720-B2 | Pyrazolo-triazine derivatives as ligands for gaba receptors | MERCK SHARP & DOHME LTD. | 2005-03-29 | — | — | US | disclosed |