Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 19/20 | 0.46 |
| ▸ | RARB | P10826 | 19/20 | 0.46 |
| ▸ | RARG | P13631 | 18/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.45 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6294287 | 1.00 | RARA (0.46) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL6292933 | 0.92 | MAPT (0.44) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL6292931 | 0.92 | MAPT (0.44) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL6297415 | 0.85 | RARA (0.64) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL6297414 | 0.85 | RARA (0.64) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL7637362 | 0.78 | RARA (0.54) | RARARARBRARG | |
| SCHEMBL6235710 | 0.76 | RARB (0.74) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL6235716 | 0.76 | RARB (0.74) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL6292733 | 0.76 | RARA (0.47) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL21538692 | 0.76 | RARA (0.39) | RARARARBRARGRXRANR2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6855832-B2 | O- or S-substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity | ALLERGAN, INC. (US) | 2005-02-15 | — | — | US | disclosed |
| US-20030078440-A1 | O- or S-substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity | ALLERGAN, INC. | 2003-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030078440-A1 | O- or S-substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity | RARB, RARA, RXRB | RARA 2/4885RARB 1/4885RARG 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.