⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL168895 | 0.72 | — | — | |
| SCHEMBL5210256 | 0.72 | — | — | |
| SCHEMBL5470 | 0.63 | — | — | |
| SCHEMBL2154663 | 0.62 | — | — | |
| SCHEMBL271854 | 0.62 | — | — | |
| SCHEMBL23717 | 0.62 | — | — | |
| Carbon Dioxide SCHEMBL4942576 | 0.58 | — | — | |
| SCHEMBL10442442 | 0.58 | — | — | |
| SCHEMBL10734809 | 0.58 | — | — | |
| Carbon Dioxide SCHEMBL1724288 | 0.54 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005037284-A1 | SORBITOL DEHYDROGENASE INHIBITOR AND HYPERTENSIVE AGENT COMBINATIONS | PFIZER PRODUCTS INC. (US) | 2005-04-28 | — | — | WO | claimed |
| US-6869943-B2 | Sorbitol dehydrogenase inhibitors | PFIZER INC (US) | 2005-03-22 | — | — | US | claimed |
| EP-1337271-B1 | COMBINATION OF GABA AGONISTS AND SORBITOL DEHYDROGENASE INHIBITORS | PFIZER PROD INC (US) | 2004-11-03 | — | — | EP | claimed |
| US-20040077671-A1 | Sorbitol dehydrogenase inhibitors | CHU-MOYER MARGARET Y (US) | 2004-04-22 | — | — | US | claimed |
| US-20030186994-A1 | Combination of statins and sorbitol dehydrogenase inhibitors | MYLARI BANAVARA L (US) | 2003-10-02 | — | — | US | claimed |
| EP-1337271-A2 | COMBINATION OF GABA AGONISTS AND SORBITOL DEHYDROGENASE INHIBITORS | Pfizer Products Inc. (US) | 2003-08-27 | — | — | EP | claimed |
| US-6602875-B2 | Sorbitol dehydrogenase inhibitors | PFIZER INC | 2003-08-05 | — | — | US | claimed |
| EP-1326591-A2 | COMBINATION OF STATINS AND SORBITOL DEHYDROGENASE INHIBITORS | Pfizer Products Inc. (US) | 2003-07-16 | — | — | EP | claimed |
| US-6544998-B2 | For treatment of suffering from diabetic complications like diabetic neuropathy, nephropathy, cardiomyopathy, retinopathy, microangiopathy, macroangiopathy, cataracts and foot ulcers. | PFIZER INC | 2003-04-08 | — | — | US | claimed |
| US-20030065179-A1 | Sorbitol dehydrogenase inhibitors | CHU-MOYER MARGARET Y (US) | 2003-04-03 | — | — | US | claimed |
| US-20020091128-A1 | Combination of gaba agonists and sorbitol dehydrogenase inhibitors | MYLARI BANAVARA L (US) | 2002-07-11 | — | — | US | claimed |
| US-6414149-B1 | TREATING DIABETES, TREATING OR PREVENTING DIABETIC COMPLICATIONS | PFIZER INC. | 2002-07-02 | — | — | US | claimed |
| WO-2002043762-A2 | COMBINATION OF GABA AGONISTS AND SORBITOL DEHYDROGENASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2002-06-06 | — | — | WO | claimed |
| WO-2002032411-A2 | COMBINATION OF STATINS AND SORBITOL DEHYDROGENASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2002-04-25 | — | — | WO | claimed |
| US-6936600-B2 | Sorbitol dehrydrogenase inhibitors | PFIZER INC (US) | 2005-08-30 | — | — | US | disclosed |
| WO-2005037284-A1 | SORBITOL DEHYDROGENASE INHIBITOR AND HYPERTENSIVE AGENT COMBINATIONS | PFIZER PRODUCTS INC. (US) | 2005-04-28 | — | — | WO | disclosed |
| US-6869943-B2 | Sorbitol dehydrogenase inhibitors | PFIZER INC (US) | 2005-03-22 | — | — | US | disclosed |
| WO-2002032411-A2 | COMBINATION OF STATINS AND SORBITOL DEHYDROGENASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2002-04-25 | — | — | WO | disclosed |
| US-20010056095-A1 | Salts of zopolrestat | MYLARI BANAVARA L (US) | 2001-12-27 | — | — | US | disclosed |
| WO-1999029640-A2 | COMPOSITIONS AND METHODS FOR MODULATING THE ACTIVITY OF FIBROBLAST GROWTH FACTOR | EISAI CO., LTD. (JP) | 1999-06-17 | — | — | WO | disclosed |