Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RIPK3 | Q9Y572 | 6/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 4/20 | 0.44 |
| ▸ | CACNB4 | O00305 | 2/20 | 0.44 |
| ▸ | CACNA1A | O00555 | 2/20 | 0.44 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.44 |
| ▸ | CACNG3 | O60359 | 2/20 | 0.44 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.44 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.44 |
| ▸ | CACNB3 | P54284 | 2/20 | 0.44 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.44 |
| ▸ | CACNG7 | P62955 | 2/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.44 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.44 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.44 |
| ▸ | CACNG1 | Q06432 | 2/20 | 0.44 |
| ▸ | CACNB2 | Q08289 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6290050 | 0.97 | KMT2A (0.51) | KMT2ARIPK3MAPK14PDE3BPDE3A | |
| SCHEMBL6294493 | 0.97 | KMT2A (0.51) | KMT2ARIPK3MAPK14PDE3BPDE3A | |
| SCHEMBL6290028 | 0.92 | KMT2A (0.47) | KMT2ARIPK3MAPK14PDE3BPDE3A | |
| SCHEMBL6291391 | 0.89 | KMT2A (0.51) | KMT2ARIPK3MAPK14PDE3BPDE3A | |
| SCHEMBL6291300 | 0.89 | KMT2A (0.51) | KMT2ARIPK3MAPK14PDE3BPDE3A | |
| SCHEMBL7008081 | 0.84 | MAPK14 (0.44) | KMT2ARIPK3MAPK14PDE3BPDE3A | |
| SCHEMBL6485382 | 0.84 | KMT2A (0.50) | KMT2APDE3BPDE3AACHECACNB4 | |
| SCHEMBL7006189 | 0.82 | RIPK3 (0.44) | KMT2ARIPK3MAPK14PDE3BPDE3A | |
| SCHEMBL6294026 | 0.82 | MAPK14 (0.46) | KMT2ARIPK3MAPK14ALDH1A1ALOX15 | |
| SCHEMBL7006565 | 0.81 | MAPK14 (0.44) | KMT2ARIPK3MAPK14PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867211-B2 | 4-Pyridyl-and 2,4-pyrimidinyl-substituted pyrrole derivatives and their use in pharmacy | MERCKLE GMBH (DE) | 2005-03-15 | — | — | US | disclosed |
| US-20030153558-A1 | 4-Pyridyl-and 2,4-pyrimidinyl-substituted pyrrole derivatives and their use in pharmacy | MERCKLE GMBH (DE) | 2003-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030153558-A1 | 4-Pyridyl-and 2,4-pyrimidinyl-substituted pyrrole derivatives and their use in pharmacy | IL4, IL2, IL5 | KMT2A 4671/4885RIPK3 2758/4885MAPK14 2214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.