Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1590803 | 0.78 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL6294643 | 0.77 | AKR1B1 (0.82) | AKR1B1 | |
| SCHEMBL9218773 | 0.71 | POLB (0.69) | AKR1B1POLB | |
| SCHEMBL1589829 | 0.67 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL9199597 | 0.66 | AKR1B1 (0.72) | AKR1B1 | |
| SCHEMBL1590415 | 0.65 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL8305041 | 0.65 | AKR1B1 (0.62) | AKR1B1 | |
| SCHEMBL23915519 | 0.64 | POLB (0.67) | AKR1B1POLB | |
| SCHEMBL9218891 | 0.64 | AKR1B1 (0.66) | AKR1B1 | |
| SCHEMBL15597471 | 0.64 | MAPT (0.68) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6936600-B2 | Sorbitol dehrydrogenase inhibitors | PFIZER INC (US) | 2005-08-30 | — | — | US | disclosed |
| US-20050020578-A1 | Sorbitol dehydrogenase inhibitors | PFIZER INC. | 2005-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020578-A1 | Sorbitol dehydrogenase inhibitors | SLC5A1, SORD, SLC5A2 | AKR1B1 5/4885POLB 4212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.