Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 1.00 |
| ▸ | RAB9A | P51151 | 9/20 | 1.00 |
| ▸ | MAPT | P10636 | 6/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.77 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.77 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.77 |
| ▸ | RELA | Q04206 | 2/20 | 0.77 |
| ▸ | PKM | P14618 | 2/20 | 0.77 |
| ▸ | HPGD | P15428 | 2/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.75 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.75 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.75 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.75 |
| ▸ | AHR | P35869 | 1/20 | 0.74 |
| ▸ | TP53 | P04637 | 3/20 | 0.72 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27179668 | 0.92 | RAB9A (0.90) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL108116 | 0.87 | NPC1 (1.00) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL23114368 | 0.87 | RAB9A (0.91) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4486236 | 0.86 | RAB9A (0.80) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL21933256 | 0.85 | RAB9A (0.73) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL18941082 | 0.85 | RAB9A (0.78) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL12700201 | 0.85 | NPC1 (0.75) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL27180046 | 0.85 | RAB9A (0.72) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL11238457 | 0.84 | RAB9A (1.00) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL13561178 | 0.84 | NPC1 (0.76) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897316-B2 | Substituted 2-phenyl-4-quinolone-3-carboxylic acid compounds and their use as antitumor agents | CHINA MEDICAL UNIVERSITY (TW) | 2005-05-24 | — | — | US | disclosed |
| US-20050032832-A1 | Substituted 2-phenyl-4-quinolone-3-carboxylic acid compounds and their use as antitumor agents | CHINA MEDICAL UNIVERSITY (TW) | 2005-02-10 | — | — | US | disclosed |
| US-4645778-A | TREATMENT OF CARDIOVASCULAR DISORDERS | RIOM LABORATOIRES C.E.R.M. "RL-CERM"S.A. (FR) | 1987-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032832-A1 | Substituted 2-phenyl-4-quinolone-3-carboxylic acid compounds and their use as antitumor agents | TP53, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CHUK | NPC1 1739/4885RAB9A 1223/4885MAPT 4128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.