Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | BDKRB1 | P46663 | 8/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1383184 | 1.00 | POLB (0.53) | POLBKCNQ1L3MBTL1CNR1KMT2A | |
| SCHEMBL631527 | 0.91 | POLB (0.53) | POLBKCNQ1L3MBTL1CNR1BDKRB1 | |
| SCHEMBL1384096 | 0.91 | POLB (0.53) | POLBKCNQ1L3MBTL1CNR1BDKRB1 | |
| SCHEMBL1381648 | 0.91 | POLB (0.52) | POLBKCNQ1L3MBTL1CNR1KMT2A | |
| SCHEMBL1384648 | 0.91 | POLB (0.52) | POLBKCNQ1L3MBTL1CNR1KMT2A | |
| SCHEMBL629859 | 0.89 | BDKRB1 (0.44) | POLBKCNQ1L3MBTL1CNR1KMT2A | |
| SCHEMBL1381715 | 0.88 | POLB (0.49) | POLBKCNQ1L3MBTL1BDKRB1HCRTR1 | |
| SCHEMBL630149 | 0.88 | POLB (0.49) | POLBKCNQ1L3MBTL1BDKRB1HCRTR1 | |
| SCHEMBL1383786 | 0.87 | FKBP1A (0.53) | POLBL3MBTL1 | |
| SCHEMBL630215 | 0.87 | FKBP1A (0.53) | POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778637-B1 | FKBP-binding composition and pharmaceutical use thereof | AVENTIS PHARMA INC (US) | 2012-02-22 | — | — | EP | claimed |
| EP-1778637-B1 | FKBP-binding composition and pharmaceutical use thereof | AVENTIS PHARMA INC (US) | 2012-02-22 | — | — | EP | disclosed |