SCHEMBL629681

SCHEMBL629681

CCCC(CCC1CCCCC1)NCc1ccc(C(=O)O)c(-c2ccccc2C)c1

nearest known ligand 0.56

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FNTA P49354 1/20 0.48
FNTB P49356 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL629300 0.85 FNTA (0.70) FNTAFNTB
SCHEMBL6626193 0.82 FNTA (0.60) FNTAFNTB
SCHEMBL7869110 0.82
SCHEMBL7869135 0.82 FNTA (0.45) FNTAFNTB
SCHEMBL7916485 0.79 FNTA (0.45) FNTAFNTB
SCHEMBL10193047 0.78 FNTA (0.54) FNTAFNTB
SCHEMBL7915252 0.77 FNTA (0.46) FNTAFNTB
SCHEMBL6626051 0.76 FNTA (0.66) FNTAFNTB
SCHEMBL6625288 0.76 FNTA (0.42) FNTAFNTB
SCHEMBL629682 0.75 FNTA (0.69) FNTAFNTB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0986384-B1 INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES UNIV PITTSBURGH (US) 2012-02-22 EP disclosed
US-6310095-B1 INHIBITING OR TREATING CANCER, TREATING INTIMAL HYPERPLASIA ASSOCIATED WITH RESTENOSIS AND ATHEROSCLEROSIS, INHIBITING POST-TRANSLATIONAL MODIFICATION OF ONCOGENIC RAS PROTEIN BY PROTEIN FARNESYLTRANSFERASE AND/OR GERANYLGERANYLTRANSFERASE UNIVERSITY OF PITTSBURGH 2001-10-30 US disclosed