Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | PGK1 | P00558 | 2/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | NOS2 | P35228 | 2/20 | 0.31 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.31 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6298755 | 0.86 | PTGDR2 (0.40) | TLR8CYP3A4POLBGAAPTGDR2 | |
| SCHEMBL6789513 | 0.81 | FFAR1 (0.44) | FFAR1CYP3A4GRM5PGK1NOX1 | |
| SCHEMBL13307710 | 0.80 | FFAR1 (0.53) | FFAR1SMN1; SMN2CYP3A4POLBGAA | |
| SCHEMBL24837837 | 0.80 | CYP2A6 (0.45) | FFAR1CYP3A4GAACYP2D6NOX1 | |
| SCHEMBL30178959 | 0.80 | CYP2A6 (0.45) | FFAR1CYP3A4GAACYP2D6NOX1 | |
| SCHEMBL6304449 | 0.80 | TLR8 (0.40) | TLR8 | |
| SCHEMBL6708034 | 0.75 | ALDH1A1 (0.43) | SMN1; SMN2GAAMEN1KMT2A | |
| SCHEMBL6116240 | 0.73 | CYP46A1 (0.36) | TLR8CYP46A1CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL6304886 | 0.72 | ALDH1A1 (0.50) | SMN1; SMN2CYP3A4GAACYP2D6MEN1 | |
| SCHEMBL17404393 | 0.70 | FFAR1 (0.42) | FFAR1CYP3A4POLBGAAGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6949661-B2 | 3-substituted-3-(substitutedsulfonyl or sulfanyl) pyrrolidine-2,5-diones useful for inhibition of farnesyl-protein transferase | WYETH HOLDINGS CORPORATION (US) | 2005-09-27 | — | — | US | disclosed |
| US-6861445-B2 | 3-Substituted-3-(substitutedsulfonyl or sulfanyl)pyrrolidine-2,5-diones useful for inhibition of farnesyl-protein transferase | WYETH HOLDINGS CORPORATION (US) | 2005-03-01 | — | — | US | disclosed |