Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.61 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17069 | 1.00 | LTA4H (0.61) | LTA4HBCHEACHELMNATSHR | |
| SCHEMBL17070 | 1.00 | LTA4H (0.61) | LTA4HBCHEACHELMNATSHR | |
| Hydrochloric Acid SCHEMBL16258 | 0.98 | LTA4H (0.59) | LTA4HBCHEACHELMNATSHR | |
| Hydrochloric Acid SCHEMBL16259 | 0.98 | LTA4H (0.59) | LTA4HBCHEACHELMNATSHR | |
| SCHEMBL3906686 | 0.86 | BCHE (0.55) | LTA4HBCHEACHELMNATSHR | |
| SCHEMBL8935940 | 0.85 | LTA4H (0.46) | LTA4HBCHEACHELMNATSHR | |
| SCHEMBL8935795 | 0.85 | LTA4H (0.46) | LTA4HBCHEACHELMNATSHR | |
| SCHEMBL10517572 | 0.84 | BCHE (0.54) | LTA4HBCHEACHELMNATSHR | |
| SCHEMBL10517566 | 0.84 | BCHE (0.54) | LTA4HBCHEACHELMNATSHR | |
| SCHEMBL3495293 | 0.84 | LTA4H (0.51) | LTA4HBCHEACHELMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6967201-B1 | for increasing activation of the 5-HT2C receptor in mammals; treatment of depression, obesity, bulimia, premenstrual syndrome, alcoholism, tobacco abuse, panic disorder | ELI LILLY AND COMPANY (US) | 2005-11-22 | — | — | US | disclosed |
| EP-1204654-B1 | BENZOFURYLPIPERAZINES: 5-HT2C SEROTONIN RECEPTOR AGONISTS | LILLY CO ELI (US) | 2003-07-23 | — | — | EP | disclosed |