Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.48 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1011633 | 0.77 | DDB1 (0.69) | EPHX2DDB1CRBNALDH1A1MEN1 | |
| SCHEMBL9850086 | 0.77 | DDB1 (0.69) | EPHX2DDB1CRBNALDH1A1MEN1 | |
| SCHEMBL26112971 | 0.76 | DRD3 (0.44) | EPHX2DDB1CRBNALDH1A1MEN1 | |
| SCHEMBL26112976 | 0.76 | DRD3 (0.44) | EPHX2DDB1CRBNALDH1A1MEN1 | |
| SCHEMBL26114530 | 0.76 | DRD3 (0.44) | EPHX2DDB1CRBNALDH1A1MEN1 | |
| SCHEMBL9850110 | 0.76 | DDB1 (0.67) | EPHX2DDB1CRBNALDH1A1MEN1 | |
| SCHEMBL14870544 | 0.75 | ALDH1A1 (0.62) | ALDH1A1KDM4EMEN1KMT2ALMNA | |
| SCHEMBL10649531 | 0.73 | EPHX2 (0.62) | EPHX2DDB1CRBNALDH1A1MEN1 | |
| SCHEMBL14870547 | 0.72 | ALDH1A1 (0.63) | ALDH1A1KDM4EMEN1KMT2AGAA | |
| SCHEMBL24200101 | 0.71 | EPHX2 (1.00) | EPHX2DDB1CRBNALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6967201-B1 | for increasing activation of the 5-HT2C receptor in mammals; treatment of depression, obesity, bulimia, premenstrual syndrome, alcoholism, tobacco abuse, panic disorder | ELI LILLY AND COMPANY (US) | 2005-11-22 | — | — | US | disclosed |
| EP-1204654-B1 | BENZOFURYLPIPERAZINES: 5-HT2C SEROTONIN RECEPTOR AGONISTS | LILLY CO ELI (US) | 2003-07-23 | — | — | EP | disclosed |