Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MGAM | O43451 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6301193 | 1.00 | KDM4E (0.60) | KDM4ESMN1; SMN2KMT2ARAB9APDGFRB | |
| SCHEMBL6378320 | 0.84 | KDM4E (0.54) | KDM4ESMN1; SMN2KMT2ARAB9APDGFRB | |
| SCHEMBL371965 | 0.84 | KDM4E (0.54) | KDM4ESMN1; SMN2KMT2ARAB9APDGFRB | |
| SCHEMBL372483 | 0.84 | KDM4E (0.54) | KDM4ESMN1; SMN2KMT2ARAB9APDGFRB | |
| SCHEMBL7738389 | 0.82 | KMT2A (0.52) | KDM4ESMN1; SMN2KMT2ARAB9APDGFRB | |
| SCHEMBL14158089 | 0.81 | PDGFRB (0.61) | KDM4ESMN1; SMN2KMT2ARAB9APDGFRB | |
| SCHEMBL17461321 | 0.81 | PDGFRB (0.61) | KDM4ESMN1; SMN2KMT2ARAB9APDGFRB | |
| SCHEMBL9997162 | 0.80 | PTGS1 (0.49) | MAPTPPARA | |
| SCHEMBL7649080 | 0.80 | PTGS1 (0.49) | MAPTPPARA | |
| SCHEMBL13699174 | 0.79 | PDGFRB (0.58) | KDM4ESMN1; SMN2KMT2ARAB9APDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6933283-B2 | 11-deoxy azalide antibacterials | ABBOTT LABORATORIES (US) | 2005-08-23 | — | — | US | disclosed |
| US-20040014953-A1 | 11-Deoxy azalide antibacterials | ABBVIE INC. | 2004-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014953-A1 | 11-Deoxy azalide antibacterials | TOP1, TOP2B, TOP2A | KDM4E 1238/4885SMN1; SMN2 780/4885KMT2A 2884/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.