Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.47 |
| ▸ | VDR | P11473 | 5/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.45 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6303779 | 0.91 | PPARG (0.46) | PPARGACSS2HDAC1HDAC6 | |
| SCHEMBL6309396 | 0.91 | S1PR1 (0.50) | PPARGVDRNR1H4ACSS2MRGPRX4 | |
| SCHEMBL6167846 | 0.86 | NR4A2 (0.52) | PPARGVDRNR1H4HDAC1HDAC6 | |
| SCHEMBL7660169 | 0.86 | PTGER1 (0.44) | PPARGHDAC1HDAC6MRGPRX4ALOX5AP | |
| SCHEMBL27467424 | 0.85 | PPARG (0.49) | PPARGHDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL6309647 | 0.85 | PPARG (0.54) | PPARGACSS2HDAC1HDAC6ALOX5AP | |
| SCHEMBL7651458 | 0.85 | PPARG (0.56) | PPARGNR1H4ACSS2HDAC1HDAC6 | |
| SCHEMBL7654248 | 0.84 | PPARG (0.52) | PPARGHDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL6303963 | 0.84 | PPARG (0.53) | PPARGHDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL6303966 | 0.84 | PPARG (0.53) | PPARGHDAC1HDAC6HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6869950-B1 | Benzimidazole derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2005-03-22 | — | — | US | disclosed |
| US-6420409-B1 | GLUCOSE TOLERANCE, DIABETES,INSULIN RESISTANCE, POLYCYSTIC OVARY SYNDROME, HYPERLIPIDEMIA, ATHEROSCLEROSIS, CARDIOVASCULAR DISORDERS, HYPERGLYCEMIA, HYPERTENSION, STENOCARDIA, PULMONARY HYPERTENSION, CONGESTIVE HEART FAILURE, | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1142880-A1 | BENZIMIDAZOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |
| EP-1020452-A1 | BENZIMIDAZOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-07-19 | — | — | EP | disclosed |