Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.42 |
| ▸ | RAB9A | P51151 | 6/20 | 0.42 |
| ▸ | HTT | P42858 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | GALR3 | O60755 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11346000 | 0.86 | NPC1 (0.53) | NPC1RAB9AHTTLMNAALDH1A1 | |
| SCHEMBL1159335 | 0.84 | NPC1 (0.62) | NPC1RAB9AHTTLMNAALDH1A1 | |
| SCHEMBL7278816 | 0.82 | NPC1 (0.63) | NPC1RAB9AHTTLMNAALDH1A1 | |
| SCHEMBL31041847 | 0.82 | NPC1 (0.63) | NPC1RAB9AHTTLMNAALDH1A1 | |
| SCHEMBL11611315 | 0.82 | NPC1 (0.63) | NPC1RAB9AHTTLMNAALDH1A1 | |
| SCHEMBL9813218 | 0.75 | SMN1; SMN2 (0.39) | SMN1; SMN2 | |
| SCHEMBL4375225 | 0.75 | CA12 (0.47) | NPC1RAB9AHTTLMNAALDH1A1 | |
| SCHEMBL9244967 | 0.75 | TERT (0.43) | LMNAALDH1A1SMN1; SMN2POLBMAPT | |
| SCHEMBL28061025 | 0.75 | SMN1; SMN2 (0.36) | NPC1RAB9AHTTLMNAALDH1A1 | |
| SCHEMBL7455057 | 0.71 | KDM4E (0.39) | NPC1RAB9AHTTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116621775-A | 2-amino-5-hydroxytetrahydronaphthalene derivative containing hydroxypyridone side chain, preparation and application thereof | 浙江大学 | 2023-08-22 | — | — | CN | claimed |
| CN-116621775-A | 2-amino-5-hydroxytetrahydronaphthalene derivative containing hydroxypyridone side chain, preparation and application thereof | 浙江大学 | 2023-08-22 | — | — | CN | disclosed |
| CN-114831116-B | Application of acetic acid phyllyl ester in preventing and treating meloidogyne incognita | 浙江大学 | 2023-01-06 | — | — | CN | disclosed |
| CN-114831116-A | Application of acetic acid leaf alcohol ester in preventing and treating meloidogyne incognita | 浙江大学 | 2022-08-02 | — | — | CN | disclosed |
| US-6890937-B2 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor | PHARMACIA CORPORATION (US) | 2005-05-10 | — | — | US | disclosed |
| US-6750233-B2 | SELECTIVITY | PHARMACIA CORPORATION | 2004-06-15 | — | — | US | disclosed |
| US-6541489-B1 | Excellent inhibitory activity of one or more matrix metalloprotease (MMP) enzymes, such as MMP-2, MMP-9, and MMP-13, while exhibiting substantially less inhibition at least of MMP- 1 | G. D. SEARLE & COMPANY | 2003-04-01 | — | — | US | disclosed |
| WO-1989009211-A1 | PROCESS FOR PRODUCING PYRID-4-ONES | THE ROYAL FREE HOSPITAL SCHOOL OF MEDICINE (GB) | 1989-10-05 | — | — | WO | disclosed |
| EP-0335745-A1 | Process for producing pyrid-4-ones | THE ROYAL FREE HOSPITAL SCHOOL OF MEDICINE (GB) | 1989-10-04 | — | — | EP | disclosed |
| US-4855420-A | Cephalosporin derivatives | ICI PHARMA (FR) | 1989-08-08 | — | — | US | disclosed |
| US-4678781-A | BACTERICIDAL ANTIBIOTICS | ICI PHARMA (FR) | 1987-07-07 | — | — | US | disclosed |