Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 16/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6307834 | 0.91 | CCR2 (0.84) | CCR2ALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL5214630 | 0.89 | CCR2 (0.80) | CCR2ALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL6599738 | 0.88 | CCR2 (1.00) | CCR2ALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL5214863 | 0.86 | CCR2 (0.76) | CCR2ALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL6307042 | 0.86 | CCR2 (0.77) | CCR2ALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL5213947 | 0.86 | CCR2 (0.77) | CCR2ALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL5221748 | 0.84 | CCR2 (0.74) | CCR2ALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL14809705 | 0.83 | CCR2 (0.70) | CCR2ALDH1A1LMNAHPGDKDM4E | |
| SCHEMBL5214639 | 0.81 | CCR2 (0.69) | CCR2ALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL5214627 | 0.81 | CCR2 (0.69) | CCR2ALDH1A1LMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6953809-B2 | Monocyte chemoattractant protein-1 inhibitor compounds | ZENECA LIMITED (GB) | 2005-10-11 | — | — | US | claimed |