Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11272645 | 0.86 | HTT (0.43) | HTTSMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL11277793 | 0.85 | HRH4 (0.44) | HTTSMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL11302866 | 0.83 | HRH4 (0.47) | HTTSMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL11270011 | 0.83 | HRH4 (0.42) | HTTSMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL11499576 | 0.82 | HTT (0.43) | HTTSMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL11498963 | 0.82 | HTT (0.41) | HTTSMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL11498697 | 0.80 | HRH4 (0.40) | HTTSMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL11271385 | 0.79 | HTT (0.46) | HTTSMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL11297804 | 0.78 | LMNA (0.53) | HTTSMN1; SMN2ALDH1A1LMNAMAPT | |
| SCHEMBL11273237 | 0.77 | HTT (0.49) | HTTSMN1; SMN2ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6927214-B1 | Non-peptide GLP-1 agonists | NOVO NORDISK A/S (DK) | 2005-08-09 | — | — | US | claimed |
| US-6927214-B1 | Non-peptide GLP-1 agonists | NOVO NORDISK A/S (DK) | 2005-08-09 | — | — | US | disclosed |
| EP-1147094-A1 | NON-PEPTIDE GLP-1 AGONISTS | NOVO NORDISK A/S (DK) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000042026-A1 | NON-PEPTIDE GLP-1 AGONISTS | NOVO NORDISK A/S (DK) | 2000-07-20 | — | — | WO | disclosed |