Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.53 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | SPR | P35270 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7242563 | 0.93 | GPR119 (0.57) | GPR119USP30SPRALDH1A1HTT | |
| SCHEMBL1769162 | 0.93 | GPR119 (0.57) | GPR119USP30SPRALDH1A1HTT | |
| SCHEMBL30193463 | 0.93 | GPR119 (0.57) | GPR119USP30SPRALDH1A1HTT | |
| SCHEMBL29548089 | 0.88 | GPR119 (0.53) | GPR119USP30SPRHRH3CHRNB2 | |
| SCHEMBL6306297 | 0.88 | GPR119 (0.53) | GPR119USP30SPRHRH3CHRNB2 | |
| SCHEMBL639943 | 0.86 | GPR119 (0.63) | GPR119USP30SPRALDH1A1HTT | |
| SCHEMBL26668746 | 0.86 | CHEK2 (0.55) | GPR119USP30CHEK2CYP2C9PRMT5 | |
| SCHEMBL7466419 | 0.82 | GPR119 (0.54) | GPR119USP30CHEK2SPR | |
| SCHEMBL16195910 | 0.81 | CHEK2 (0.49) | USP30CHEK2CYP2C9PRMT5WDR77 | |
| SCHEMBL14780123 | 0.81 | CHEK2 (0.49) | USP30CHEK2CYP2C9PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6888001-B2 | Selective modulators of the nicotinic acetylcholine receptor useful in the treatment of pain, Alzheimer's disease, memory loss or dementia or loss of motor function. | LEE JUNG S (US) | 2005-05-03 | — | — | US | disclosed |
| EP-1107965-B1 | PYRIDYL ETHERS AND THIOETHERS AS LIGANDS FOR NICOTINIC ACETYLCHOLINE RECEPTOR AND ITS THERAPEUTIC APPLICATION | ORTHO MCNEIL PHARM INC (US) | 2004-08-11 | — | — | EP | disclosed |
| US-20030207858-A1 | Selective modulators of the nicotinic acetylcholine receptor useful in the treatment of pain, Alzheimer's disease, memory loss or dementia or loss of motor function. | LEE JUNG S (US) | 2003-11-06 | — | — | US | disclosed |
| US-6562847-B1 | Useful in the treatment of pain, Alzheimer's disease, memory loss or dementia or loss of motor function | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-05-13 | — | — | US | disclosed |
| EP-1107965-A1 | PYRIDYL ETHERS AND THIOETHERS AS LIGANDS FOR NICOTINIC ACETYLCHOLINE RECEPTOR AND ITS THERAPEUTIC APPLICATION | Ortho-McNeil Pharmaceutical, Inc. (US) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000010997-A1 | PYRIDYL ETHERS AND THIOETHERS AS LIGANDS FOR NICOTINIC ACETYLCHOLINE RECEPTOR AND ITS THERAPEUTIC APPLICATION | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2000-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207858-A1 | Selective modulators of the nicotinic acetylcholine receptor useful in the treatment of pain, Alzheimer's disease, memory loss or dementia or loss of motor function. | CHRM1, CHRM5, CHRM2 | GPR119 338/4885USP30 4398/4885CHEK2 2811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.