Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 3/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTR5A | P47898 | 1/20 | 0.37 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6305368 | 0.83 | IDO1 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8292984 | 0.80 | IDO1 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4552155 | 0.76 | IDO1 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL10109761 | 0.71 | IDO1 (0.58) | IDO1GSK3BTDO2MAPTKDM4E | |
| SCHEMBL13803044 | 0.71 | PSEN1 (0.60) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6305363 | 0.71 | HTR2A (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3157916 | 0.70 | IDO1 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8294613 | 0.70 | BRPF1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3163873 | 0.70 | IDO1 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4115729 | 0.70 | IDO1 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6958330-B1 | Polycyclic α-amino-ε-caprolactams and related compounds | ELAN PHARMACEUTICALS, INC. (US) | 2005-10-25 | — | — | US | disclosed |