Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 6/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 6/20 | 0.49 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | FPR2 | P25090 | 4/20 | 0.40 |
| ▸ | PROKR1 | Q8TCW9 | 4/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6305784 | 1.00 | CRHBP (0.49) | CRHBPCRHR2MCOLN3KMT2AFPR2 | |
| SCHEMBL6303738 | 0.92 | CRHBP (0.49) | CRHBPCRHR2MCOLN3KMT2AFPR2 | |
| SCHEMBL6303741 | 0.92 | CRHBP (0.49) | CRHBPCRHR2MCOLN3KMT2AFPR2 | |
| SCHEMBL6303803 | 0.92 | CRHBP (0.47) | CRHBPCRHR2MCOLN3KMT2AFPR2 | |
| SCHEMBL6303808 | 0.92 | CRHBP (0.47) | CRHBPCRHR2MCOLN3KMT2AFPR2 | |
| SCHEMBL6303780 | 0.86 | CRHBP (0.66) | CRHBPCRHR2MCOLN3KMT2AGMNN | |
| SCHEMBL6303778 | 0.86 | CRHBP (0.66) | CRHBPCRHR2MCOLN3KMT2AGMNN | |
| SCHEMBL6311367 | 0.86 | CRHBP (0.47) | CRHBPCRHR2MCOLN3KMT2AFPR2 | |
| SCHEMBL6311363 | 0.86 | CRHBP (0.47) | CRHBPCRHR2MCOLN3KMT2AFPR2 | |
| SCHEMBL6303617 | 0.85 | CRHBP (0.52) | CRHBPCRHR2MCOLN3KMT2AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6977265-B2 | Piperidine CCR-3 receptor antagonists | ROCHE PALO ALTO LLC (US) | 2005-12-20 | — | — | US | disclosed |