Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 8/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6304845 | 0.94 | PARP1 (0.39) | PARP1HSD17B10ALOX15SMYD3MAPK1 | |
| SCHEMBL6302669 | 0.91 | PARP1 (0.32) | PARP1HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL6302932 | 0.91 | PARP1 (0.34) | PARP1HSD17B10ALOX15SMYD3 | |
| SCHEMBL6303037 | 0.90 | PARP1 (0.36) | PARP1HSD17B10ALOX15SMYD3PDE3B | |
| SCHEMBL6305893 | 0.86 | PARP1 (0.54) | PARP1HSD17B10ALOX15SMYD3MAPK1 | |
| SCHEMBL6309334 | 0.85 | HDAC3 (0.31) | HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL6302634 | 0.85 | PARP1 (0.33) | PARP1SMYD3 | |
| SCHEMBL7713376 | 0.84 | PARP1 (0.56) | PARP1HSD17B10ALOX15SMYD3MAPK1 | |
| SCHEMBL6302723 | 0.83 | PARP1 (0.47) | PARP1HSD17B10ALOX15SMYD3MAPK1 | |
| SCHEMBL6308969 | 0.82 | PARP1 (0.46) | PARP1HSD17B10ALOX15SMYD3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6841550-B1 | Benzoxazine and benzothiazine derivatives and their use in medicines | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-01-11 | — | — | US | disclosed |
| EP-1114037-B1 | BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN MEDICINES | SCHERING AG (DE) | 2004-05-12 | — | — | EP | disclosed |