Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.70 |
| ▸ | MEN1 | O00255 | 4/20 | 0.70 |
| ▸ | TSHR | P16473 | 2/20 | 0.70 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9052600 | 0.87 | HTT (0.71) | KMT2AMEN1TSHRLMNAALDH1A1 | |
| SCHEMBL27577317 | 0.84 | MEN1 (0.72) | KMT2AMEN1TSHRLMNAALDH1A1 | |
| SCHEMBL20708692 | 0.83 | KMT2A (1.00) | KMT2AMEN1TSHRLMNAALDH1A1 | |
| SCHEMBL27664371 | 0.81 | MAPT (0.54) | KMT2AMEN1TSHRLMNAALDH1A1 | |
| SCHEMBL631024 | 0.79 | AKR1C3 (0.65) | KMT2ATSHRLMNAALDH1A1HTT | |
| SCHEMBL10144699 | 0.79 | KMT2A (0.70) | KMT2AMEN1TSHRLMNAALDH1A1 | |
| SCHEMBL28262527 | 0.79 | TSHR (0.64) | KMT2AMEN1TSHRLMNAALDH1A1 | |
| SCHEMBL14452912 | 0.78 | TSHR (0.71) | KMT2AMEN1TSHRLMNAALDH1A1 | |
| SCHEMBL16276043 | 0.77 | MAPT (0.63) | KMT2AMEN1TSHRLMNAALDH1A1 | |
| SCHEMBL13292998 | 0.77 | MEN1 (0.57) | KMT2AMEN1TSHRLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234992-B1 | PIPERAZINE DERIVATIVES AND THEIR USE AS LEPTIN RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2012-02-22 | — | — | EP | claimed |
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |