Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 9/20 | 0.33 |
| ▸ | JAK1 | P23458 | 5/20 | 0.33 |
| ▸ | JAK2 | O60674 | 4/20 | 0.33 |
| ▸ | JAK3 | P52333 | 3/20 | 0.33 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.32 |
| ▸ | FKBP1B | P68106 | 1/20 | 0.32 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10099139 | 0.85 | SCN9A (0.42) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL574992 | 0.84 | JAK2 (0.32) | JAK1JAK2JAK3 | |
| SCHEMBL567231 | 0.83 | DGAT1 (0.32) | MTORJAK1JAK2CTSS | |
| SCHEMBL565566 | 0.83 | GRM2 (0.35) | JAK1JAK2JAK3 | |
| SCHEMBL566635 | 0.83 | GRM2 (0.35) | JAK1JAK2JAK3 | |
| SCHEMBL10099301 | 0.83 | DGAT1 (0.37) | — | |
| SCHEMBL10099143 | 0.82 | SCN9A (0.40) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL16477593 | 0.80 | JAK1 (0.42) | MTORJAK1JAK2JAK3FKBP1A | |
| SCHEMBL10099319 | 0.80 | DGAT1 (0.31) | — | |
| SCHEMBL10099138 | 0.79 | JAK2 (0.33) | JAK1JAK2JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2420502-A1 | FUSED PYRROLOPYRIDINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2012-02-22 | — | — | EP | disclosed |
| US-20120034250-A1 | CONDENSED PYRROLOPYRIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120034250-A1 | CONDENSED PYRROLOPYRIDINE DERIVATIVE | JAK2, JAK1, JAK3 | MTOR 245/4885JAK1 2/4885JAK2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.