SCHEMBL6308946

SCHEMBL6308946

O=C1O[C@@H](CNC(=S)C(F)F)CN1c1ccc(N2CCCS(O)(O)CC2)c(F)c1

nearest known ligand 0.56

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAOB P27338 6/20 0.56
MAOA P21397 2/20 0.56
LMNA P02545 1/20 0.56
PTGS1 P23219 1/20 0.56
CALML3 P27482 1/20 0.56
SDHA P31040 1/20 0.56
F10 P00742 14/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6309582 0.97 MAOB (0.59) MAOBMAOALMNAPTGS1CALML3
SCHEMBL6308950 0.92 F10 (0.63) MAOBMAOALMNAPTGS1CALML3
SCHEMBL6309573 0.90 F10 (0.67) MAOBMAOALMNAPTGS1CALML3
SCHEMBL6307004 0.89 MAOA (0.43) MAOBMAOALMNAPTGS1CALML3
SCHEMBL6306773 0.89 F10 (0.49) MAOBMAOALMNAPTGS1CALML3
SCHEMBL6313273 0.87 MAOB (0.62) MAOBMAOALMNAPTGS1CALML3
SCHEMBL6163915 0.86 MAOB (0.75) MAOBMAOALMNAPTGS1CALML3
SCHEMBL6160678 0.86 MAOB (0.75) MAOBMAOALMNAPTGS1CALML3
SCHEMBL6250302 0.85 F10 (0.66) MAOBMAOALMNAPTGS1CALML3
SCHEMBL6314916 0.85 MAOA (0.45) MAOBMAOALMNAPTGS1CALML3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040077626-A1 Difluorothioacetamides of oxazolidinones as antibacterial agents PHARMACIA & UPJOHN COMPANY 2004-04-22 US claimed
US-6927229-B2 Difluorothioacetamides of oxazolidinones as antibacterial agents PHARMACIA & UPJOHN COMPANY (US) 2005-08-09 US disclosed
US-20040077626-A1 Difluorothioacetamides of oxazolidinones as antibacterial agents PHARMACIA & UPJOHN COMPANY 2004-04-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040077626-A1 Difluorothioacetamides of oxazolidinones as antibacterial agents AADAC, DLAT, OXA1L MAOB 3725/4885MAOA 3135/4885LMNA 4820/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.