SCHEMBL6309281

SCHEMBL6309281

CCCC[C@H](NC(=O)OC(C)(C)C)C(=O)NC1C(=O)N(C)c2ccccc2N=C1c1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 12/20 0.52
CCKAR P32238 3/20 0.49
CCKBR P32239 3/20 0.49
CTSK P43235 5/20 0.44
CTSS P25774 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6306657 0.88 SCN9A (0.48) SCN9ACCKARCCKBRCTSK
SCHEMBL6306266 0.86 SCN9A (0.49) SCN9ACCKARCCKBR
SCHEMBL6306060 0.82 CCKBR (0.44) CCKBR
SCHEMBL6301463 0.82 SCN9A (0.56) SCN9ACCKARCCKBRCTSKCTSS
Hydrochloric Acid SCHEMBL6312492 0.82 CCKBR (0.43) CCKBR
SCHEMBL6314300 0.75 PSEN1 (0.45) CCKBR
Hydrochloric Acid SCHEMBL6308092 0.74 PSEN1 (0.44) CCKBR
SCHEMBL6313460 0.74 SCN9A (0.50) SCN9ACCKARCCKBRCTSK
SCHEMBL6307759 0.73 SCN9A (0.45) SCN9ACCKARCCKBR
SCHEMBL4413008 0.72 PSEN1 (0.52) SCN9ACCKARCCKBR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6958330-B1 Polycyclic α-amino-ε-caprolactams and related compounds ELAN PHARMACEUTICALS, INC. (US) 2005-10-25 US disclosed