Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6309335 | 1.00 | MEN1 (0.57) | MEN1KMT2AEGFRNPC1RAB9A | |
| SCHEMBL6309356 | 0.92 | MEN1 (0.57) | MEN1KMT2ANPC1RAB9ARXFP1 | |
| SCHEMBL6309360 | 0.92 | MEN1 (0.57) | MEN1KMT2ANPC1RAB9ARXFP1 | |
| SCHEMBL7546935 | 0.87 | MEN1 (0.60) | MEN1KMT2AEGFRNPC1RAB9A | |
| SCHEMBL7546931 | 0.87 | MEN1 (0.60) | MEN1KMT2AEGFRNPC1RAB9A | |
| SCHEMBL6308082 | 0.86 | MEN1 (0.77) | MEN1KMT2ANPC1RAB9ARXFP1 | |
| SCHEMBL6308089 | 0.86 | MEN1 (0.77) | MEN1KMT2ANPC1RAB9ARXFP1 | |
| SCHEMBL6314623 | 0.83 | MEN1 (0.58) | MEN1KMT2AEGFRMAPTBLM | |
| SCHEMBL6314628 | 0.83 | MEN1 (0.58) | MEN1KMT2AEGFRMAPTBLM | |
| SCHEMBL6306210 | 0.82 | KMT2A (0.51) | MEN1KMT2ANPC1RAB9ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890930-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |