Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.60 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.52 |
| ▸ | TUBB | P07437 | 2/20 | 0.52 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.52 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.52 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.52 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.52 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.52 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.52 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.52 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.52 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.52 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.52 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7546935 | 1.00 | MEN1 (0.60) | MEN1KMT2AEGFRLMNASMN1; SMN2 | |
| SCHEMBL6310500 | 0.92 | TUBB4A (0.61) | MEN1KMT2AEGFRLMNASMN1; SMN2 | |
| SCHEMBL6310494 | 0.92 | TUBB4A (0.61) | MEN1KMT2AEGFRLMNASMN1; SMN2 | |
| SCHEMBL6315133 | 0.87 | KMT2A (0.77) | MEN1KMT2ALMNASMN1; SMN2KDM4E | |
| SCHEMBL6315127 | 0.87 | KMT2A (0.77) | MEN1KMT2ALMNASMN1; SMN2KDM4E | |
| SCHEMBL6309335 | 0.87 | MEN1 (0.57) | MEN1KMT2AEGFRLMNASMN1; SMN2 | |
| SCHEMBL6309338 | 0.87 | MEN1 (0.57) | MEN1KMT2AEGFRLMNASMN1; SMN2 | |
| SCHEMBL6313885 | 0.84 | ALDH1A1 (0.49) | MEN1KMT2AEGFRLMNASMN1; SMN2 | |
| SCHEMBL6313888 | 0.84 | ALDH1A1 (0.49) | MEN1KMT2AEGFRLMNASMN1; SMN2 | |
| SCHEMBL6315896 | 0.81 | MEN1 (0.58) | MEN1KMT2ALMNASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |