Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599798 | 0.82 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL5599533 | 0.81 | CRHR1 (0.45) | CRHR1 | |
| SCHEMBL5599508 | 0.76 | CRHR1 (0.43) | CRHR1 | |
| SCHEMBL6303211 | 0.76 | CRHR1 (0.45) | CRHR1 | |
| SCHEMBL6303429 | 0.75 | CRHR1 (0.42) | CRHR1 | |
| SCHEMBL6303157 | 0.75 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL5600008 | 0.73 | CRHR1 (0.37) | CRHR1 | |
| SCHEMBL5600415 | 0.73 | CRHR1 (0.45) | CRHR1 | |
| SCHEMBL5600172 | 0.73 | CRHR1 (0.37) | CRHR1 | |
| SCHEMBL5599500 | 0.73 | CRHR1 (0.45) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925298-B1 | SUBSTITUTED 6,6-HETERO-BICYCLIC DERIVATIVES | PFIZER (US) | 2004-04-14 | — | — | EP | claimed |
| US-20030114671-A1 | Substituted6,6-hetero-bicyclicderivatives | CHEN YUHPYNG L (US) | 2003-06-19 | — | — | US | claimed |
| EP-0925298-A1 | SUBSTITUTED 6,6-HETERO-BICYCLIC DERIVATIVES | PFIZER INC. (US) | 1999-06-30 | — | — | EP | claimed |
| WO-1998008846-A1 | SUBSTITUTED 6,6-HETERO-BICYCLIC DERIVATIVES | PFIZER INC. (US) | 1998-03-05 | — | — | WO | claimed |
| US-6875769-B2 | Substituted6,6-hetero-bicyclicderivatives | PFIZER INC. (US) | 2005-04-05 | — | — | US | disclosed |
| EP-0925298-B1 | SUBSTITUTED 6,6-HETERO-BICYCLIC DERIVATIVES | PFIZER (US) | 2004-04-14 | — | — | EP | disclosed |
| US-20030114671-A1 | Substituted6,6-hetero-bicyclicderivatives | CHEN YUHPYNG L (US) | 2003-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030114671-A1 | Substituted6,6-hetero-bicyclicderivatives | CYP2D6, CYP2B6, CYP2A6 | CRHR1 2119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.