Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 4/20 | 0.47 |
| ▸ | SLC6A5 | Q9Y345 | 11/20 | 0.42 |
| ▸ | DRD4 | P21917 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6303009 | 0.95 | CHRNA7 (0.53) | CHRNA7SLC6A5DRD4HTR2A | |
| SCHEMBL6630482 | 0.95 | CHRNA7 (0.53) | CHRNA7SLC6A5DRD4HTR2A | |
| SCHEMBL6303005 | 0.95 | CHRNA7 (0.53) | CHRNA7SLC6A5DRD4HTR2A | |
| SCHEMBL6303294 | 0.86 | CHRNA7 (0.50) | CHRNA7USP30 | |
| SCHEMBL6883289 | 0.85 | CHRNA7 (0.52) | CHRNA7 | |
| SCHEMBL6305443 | 0.85 | CHRNA7 (0.57) | CHRNA7SLC6A5USP30 | |
| SCHEMBL6310757 | 0.84 | CHRNA7 (0.48) | CHRNA7DRD4HTR2AUSP30 | |
| SCHEMBL6303458 | 0.83 | CHRNA7 (0.46) | CHRNA7SLC6A5 | |
| SCHEMBL6303630 | 0.82 | CHRNA7 (0.48) | CHRNA7SLC6A5USP30 | |
| SCHEMBL6631814 | 0.81 | CHRNA7 (0.57) | CHRNA7USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6852716-B2 | Substituted-aryl compounds for treatment of disease | PFIZER INC (US) | 2005-02-08 | — | — | US | claimed |
| US-20030236279-A1 | Substituted-aryl compounds for treatment of disease | PHARMACIA & UPJOHN COMPANY | 2003-12-25 | — | — | US | claimed |
| US-6852716-B2 | Substituted-aryl compounds for treatment of disease | PFIZER INC (US) | 2005-02-08 | — | — | US | disclosed |
| EP-1480977-A2 | SUBSTITUTED ARYL COMPOUNDS FOR TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-12-01 | — | — | EP | disclosed |
| US-20030236279-A1 | Substituted-aryl compounds for treatment of disease | PHARMACIA & UPJOHN COMPANY | 2003-12-25 | — | — | US | disclosed |
| WO-2003070728-A2 | AZABICYCLO-SUBSTITUTED BENZOYLAMIDES AND THIOAMIDES FOR TREATMENT OF CNS-RELATED DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 2003-08-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030236279-A1 | Substituted-aryl compounds for treatment of disease | NAT1, CYP7A1, CYP7B1 | CHRNA7 2937/4885SLC6A5 1715/4885DRD4 3850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.