CYP7B1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL10269436	0.51	1/20
SCHEMBL19625269	0.51	1/20
SCHEMBL19634237	0.51	1/20
SCHEMBL21392306	0.43	1/20
SCHEMBL21392307	0.43	1/20

Clinical trials — most relevant to CYP7B1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Silymarin in Rheumatoid Arthritis Patients Treated With Methotrexate	PHASE4	NOT_YET_RECRUITING
The Role of CYP8B1 Polymorphisms in Modulating the Biochemical Pathways Affected by SGLT2 Inhibitors in T2DM and Obesity	PHASE4	COMPLETED
Olutasidenib DDI Study in Patients With IDH1 Mutation Positive Malignancies	PHASE4	RECRUITING
Cholestatic Drug-induced Liver Injury	PHASE4	UNKNOWN
3 Month PHI PAD PoM Study	PHASE2	COMPLETED
Androgen Reduction in Congenital Adrenal Hyperplasia	PHASE2	WITHDRAWN
Repeat Dose Safety and Efficacy Study for Compound to Treat Anemia	PHASE2	COMPLETED
Efavirenz for Patients With Alzheimer's Disease	PHASE1	COMPLETED
Cocktail Approach for Cytochrome P450 and P-glycoprotein Activity Assessment Using Dried Blood Spot	PHASE1	COMPLETED
Diindolylmethane in Treating Patients Undergoing Surgery for Stage I or Stage II Prostate Cancer	PHASE1	COMPLETED
A Study of CYP-001 for the Treatment of Steroid-Resistant Acute Graft Versus Host Disease	PHASE1	COMPLETED
The Antibiotic Rifampin to Reduce High Levels of Blood and Urine Calcium in IIH	PHASE1	UNKNOWN
Effect of Dexamethasone on CYP Enzyme Activity in Healthy Male Subjects	PHASE1	NOT_YET_RECRUITING
Gene Expression, Metabolomic, Microbiome, and Calcium Metabolism in Response to Varied Vitamin D Dosages	nan	COMPLETED
Mutation Analysis of 17α-Hydroxylase	nan	UNKNOWN
Drug Metabolizing Enzyme and Transporter Function in Chronic Kidney Disease	nan	COMPLETED
Biomarkers in Bone Marrow and Blood Samples From Patients With Prostate Cancer Treated With Ketoconazole	nan	WITHDRAWN
The Metabolic Profile in Intrahepatic Cholestasis of Pregnancy and Diabetes Mellitus	nan	COMPLETED
The Clinical and Economic Impact of Pharmacogenomic Testing for Tamoxifen Metabolism in Postmenopausal Women Receiving Tamoxifen for Prevention of Recurrent Breast Cancer	nan	COMPLETED
Study of Smith-Lemli-Opitz Syndrome	nan	COMPLETED
PhaRmacOgenetics and Therapeutic Drug Monitoring In SchizophrEnia	nan	NOT_YET_RECRUITING
Polycystic Ovary Syndrome in Type 1 Diabetes	nan	NOT_YET_RECRUITING
Cholesterol and CYP3A4/5 Metabolism Across Pregnancy and Postpartum	nan	COMPLETED
Hypercalcemia After Paraffin Oil Injection	nan	RECRUITING
Genetic, Dietary and Environmental Influences on Vitamin D Metabolism	nan	COMPLETED
Replacement of Vitamin D in Patients With Active Tuberculosis	nan	COMPLETED
Connecting Breath and Mind for CYP With Long COVID	nan	UNKNOWN
Linear Growth of Children With Congenital Adrenal Hyperplasia	nan	UNKNOWN
Evaluation and Predictive Value of Genetic Polymorphisms in the Management of Hormonal Treatment of Prostate Cancer	nan	UNKNOWN
Measurement of Risperidone and 9-Hydroxyrisperidone in Plasma and Saliva	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a CYP7B1 binder may also engage these)

Protein	Name	Similarity
Q60991	—	0.999	Q60991 →
F1RE08	—	0.994	F1RE08 →
Q63688	—	0.992	Q63688 →
O88962	—	0.990	O88962 →
CYP8B1	7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase	0.989	landscape →
E1BHJ4	—	0.987	E1BHJ4 →
O02766	—	0.987	O02766 →
G3V7X8	—	0.985	G3V7X8 →
Q7YRB2	—	0.985	Q7YRB2 →
O46491	—	0.983	O46491 →
Q08D50	—	0.983	Q08D50 →
Q64505	—	0.983	Q64505 →
CYP26B1	Cytochrome P450 26B1	0.982	landscape →
Q9JKJ9	—	0.982	Q9JKJ9 →
P51542	—	0.982	P51542 →
P46634	—	0.980	P46634 →
O93323	—	0.980	O93323 →
Q811W2	—	0.980	Q811W2 →
A0A9Y1LLN2	—	0.980	A0A9Y1LLN2 →
P0DOX0	—	0.979	P0DOX0 →
P00189	—	0.979	P00189 →
P79739	—	0.978	P79739 →
Q50EK5	—	0.978	Q50EK5 →
Q92045	—	0.977	Q92045 →
P18125	—	0.977	P18125 →
CYP7A1	Cytochrome P450 7A1	0.976	landscape →
Q9NYL5	—	0.976	Q9NYL5 →
Q6EIG3	—	0.975	Q6EIG3 →
O23051	—	0.975	O23051 →
Q84KI1	—	0.975	Q84KI1 →