Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 7/20 | 0.48 |
| ▸ | ICAM1 | P05362 | 7/20 | 0.48 |
| ▸ | ITGAL | P20701 | 7/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6310390 | 0.89 | ITGB2 (0.44) | ITGB2ICAM1ITGALHPGDSMN1; SMN2 | |
| SCHEMBL6311335 | 0.88 | ITGB2 (0.46) | ITGB2ICAM1ITGALHPGDSMN1; SMN2 | |
| SCHEMBL6309482 | 0.88 | ITGB2 (0.43) | ITGB2ICAM1ITGALHPGDSMN1; SMN2 | |
| SCHEMBL5830523 | 0.81 | ITGB2 (0.65) | ITGB2ICAM1ITGALHPGDSMN1; SMN2 | |
| SCHEMBL6196917 | 0.81 | ITGB2 (0.49) | ITGB2ICAM1ITGALHPGDSMN1; SMN2 | |
| SCHEMBL6198619 | 0.78 | ITGB2 (0.57) | ITGB2ICAM1ITGALSMN1; SMN2RAB9A | |
| SCHEMBL5830251 | 0.76 | ITGB2 (0.68) | ITGB2ICAM1ITGALSMN1; SMN2RAB9A | |
| SCHEMBL5829927 | 0.76 | ITGB2 (0.68) | ITGB2ICAM1ITGALHPGDSMN1; SMN2 | |
| SCHEMBL5830329 | 0.74 | ITGB2 (0.70) | ITGB2ICAM1ITGALSMN1; SMN2RAB9A | |
| SCHEMBL6199881 | 0.73 | ITGAL (0.46) | ITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878700-B1 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds | ABBOTT LABORATORIES (US) | 2005-04-12 | — | — | US | claimed |
| US-6878700-B1 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds | ABBOTT LABORATORIES (US) | 2005-04-12 | — | — | US | disclosed |
| US-6867203-B2 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds | ABBOTT LABORATORIES (US) | 2005-03-15 | — | — | US | disclosed |
| US-20040116518-A1 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds | ABBOTT LABORATORIES | 2004-06-17 | — | — | US | disclosed |