Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 1/20 | 0.67 |
| ▸ | FNTB | P49356 | 1/20 | 0.67 |
| ▸ | CYP19A1 | P11511 | 10/20 | 0.62 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.54 |
| ▸ | CNR1 | P21554 | 4/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | IDO1 | P14902 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7092407 | 0.92 | FNTA (0.56) | FNTAFNTBCYP19A1CYP17A1CNR1 | |
| SCHEMBL6303535 | 0.80 | FNTA (1.00) | FNTAFNTBCYP19A1CYP17A1CNR1 | |
| SCHEMBL11370543 | 0.80 | CYP19A1 (0.85) | FNTAFNTBCYP19A1CYP17A1CNR1 | |
| Nitric Acid SCHEMBL6873533 | 0.80 | FNTA (0.58) | FNTAFNTBCYP19A1CYP17A1CNR1 | |
| Nitric Acid SCHEMBL6873528 | 0.80 | FNTA (0.58) | FNTAFNTBCYP19A1CYP17A1CNR1 | |
| SCHEMBL6867606 | 0.79 | FNTA (0.67) | FNTAFNTBCYP19A1CYP17A1CNR1 | |
| SCHEMBL11366789 | 0.78 | CYP19A1 (1.00) | FNTAFNTBCYP19A1CYP17A1CNR1 | |
| SCHEMBL11353276 | 0.77 | CYP19A1 (0.91) | FNTAFNTBCYP19A1CYP17A1CNR1 | |
| SCHEMBL11643112 | 0.77 | CYP17A1 (0.76) | FNTAFNTBCYP19A1CYP17A1CNR1 | |
| SCHEMBL10693298 | 0.75 | CYP19A1 (1.00) | CYP19A1CYP17A1CNR1CYP3A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6914066-B2 | 1,2-annelated quinoline derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-07-05 | — | — | US | disclosed |
| CN-1178938-C | 1,2-annelated quinoline derivatives | ղɭҩҵ����˾ | 2004-12-08 | — | — | CN | disclosed |
| US-20030119843-A1 | 1,2-annelated quinoline derivatives | JANSSEN PHARMACEUTICA, N.V. | 2003-06-26 | — | — | US | disclosed |
| EP-1140935-B1 | 1,2-ANNELATED QUINOLINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-05-14 | — | — | EP | disclosed |
| US-6458800-B1 | 1,2-annelated quinoline derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-10-01 | — | — | US | disclosed |
| CN-1331693-A | 1,2-annelated quinoline derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2002-01-16 | — | — | CN | disclosed |
| EP-1140935-A2 | 1,2-ANNELATED QUINOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039082-A2 | 1,2-ANNELATED QUINOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-07-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030119843-A1 | 1,2-annelated quinoline derivatives | NAT1, CYP7A1, CYP4A11 | FNTA 19/4885FNTB 27/4885CYP19A1 549/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.