Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 1/20 | 0.56 |
| ▸ | FNTB | P49356 | 1/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 13/20 | 0.54 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CNR1 | P21554 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | IDO1 | P14902 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6310693 | 0.92 | FNTA (0.67) | FNTAFNTBCYP19A1CYP17A1CYP3A4 | |
| SCHEMBL6309676 | 0.79 | CYP19A1 (0.44) | FNTAFNTBCYP19A1CYP17A1CYP3A4 | |
| SCHEMBL6305490 | 0.78 | FNTA (0.81) | FNTAFNTBCYP19A1CYP17A1CYP3A4 | |
| SCHEMBL1683554 | 0.77 | CYP19A1 (0.51) | FNTAFNTBCYP19A1CYP17A1CYP3A4 | |
| SCHEMBL11827110 | 0.74 | MAPK1 (0.47) | MEN1ALDH1A1MAPTMAPK1KMT2A | |
| SCHEMBL10642922 | 0.74 | CYP19A1 (1.00) | CYP19A1CYP17A1CYP3A4CNR1MEN1 | |
| Oxalic Acid SCHEMBL7668360 | 0.73 | FNTA (0.48) | FNTAFNTBCYP19A1CYP17A1CYP3A4 | |
| Oxalic Acid SCHEMBL7668363 | 0.73 | FNTA (0.48) | FNTAFNTBCYP19A1CYP17A1CYP3A4 | |
| SCHEMBL11643112 | 0.73 | CYP17A1 (0.76) | FNTAFNTBCYP19A1CYP17A1CYP3A4 | |
| SCHEMBL9664901 | 0.72 | CYP19A1 (0.53) | CYP19A1CYP17A1CYP3A4CNR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1178938-C | 1,2-annelated quinoline derivatives | ղɭҩҵ����˾ | 2004-12-08 | — | — | CN | disclosed |
| EP-1140935-B1 | 1,2-ANNELATED QUINOLINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-05-14 | — | — | EP | disclosed |
| US-6458800-B1 | 1,2-annelated quinoline derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-10-01 | — | — | US | disclosed |
| CN-1331693-A | 1,2-annelated quinoline derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2002-01-16 | — | — | CN | disclosed |
| EP-1140935-A2 | 1,2-ANNELATED QUINOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039082-A2 | 1,2-ANNELATED QUINOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-07-06 | — | — | WO | disclosed |