SCHEMBL6311027

SCHEMBL6311027

Cc1c(-c2csc(-c3ccccc3)n2)c(Cl)c2c(nc3ccccn32)c1C#N

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SREBF2 Q12772 1/20 0.38
KMT2A Q03164 4/20 0.38
MEN1 O00255 3/20 0.38
KDM4E B2RXH2 5/20 0.37
AR P10275 1/20 0.37
RAB9A P51151 4/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
NPC1 O15118 2/20 0.35
CYP19A1 P11511 2/20 0.35
CASP3 P42574 1/20 0.35
SENP8 Q96LD8 1/20 0.35
SENP7 Q9BQF6 1/20 0.35
SENP6 Q9GZR1 1/20 0.35
ALDH1A1 P00352 4/20 0.35
L3MBTL1 Q9Y468 3/20 0.35
HTT P42858 2/20 0.35
HPGD P15428 2/20 0.35
APOBEC3G Q9HC16 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
MAPT P10636 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6310683 0.88 KDM4E (0.36) KMT2AMEN1KDM4ERAB9ASMN1; SMN2
SCHEMBL6310367 0.86 HTT (0.43) KDM4ERAB9ASMN1; SMN2NPC1ALDH1A1
SCHEMBL6311782 0.85 KDM4E (0.34) KMT2AMEN1KDM4ERAB9ASMN1; SMN2
SCHEMBL6311042 0.79 KDM4E (0.45) KMT2AMEN1KDM4ESMN1; SMN2ALDH1A1
SCHEMBL6319505 0.78 KDM4E (0.34) KMT2AMEN1KDM4ERAB9ANPC1
SCHEMBL6312786 0.78 KDM4E (0.44) KMT2AMEN1KDM4ERAB9ASMN1; SMN2
SCHEMBL6312626 0.77 PIK3CD (0.45) KMT2AKDM4ERAB9ANPC1ALDH1A1
SCHEMBL6311836 0.76 GRM2 (0.41) KMT2AMEN1KDM4EARRAB9A
SCHEMBL6311468 0.75 HPGD (0.45) KMT2AMEN1KDM4ERAB9ASMN1; SMN2
SCHEMBL6309849 0.74 KDM4E (0.41) KMT2AMEN1KDM4ERAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050113397-A1 Imidazo[1,2-a]pyridine derivative DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2005-05-26 US disclosed
EP-1479681-A1 IMIDAZO(1,2-a)PYRIDINE DERIVATIVE DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2004-11-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050113397-A1 Imidazo[1,2-a]pyridine derivative MANBA, MAN2B1, ERG28 SREBF2 1766/4885KMT2A 4210/4885MEN1 2268/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.