Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 16/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 16/20 | 0.40 |
| ▸ | ITGAL | P20701 | 16/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6489137 | 0.90 | ITGB2 (0.41) | ITGB2ICAM1ITGALPDE7AKMT2A | |
| SCHEMBL6198619 | 0.84 | ITGB2 (0.57) | ITGB2ICAM1ITGALKMT2A | |
| SCHEMBL5830251 | 0.74 | ITGB2 (0.68) | ITGB2ICAM1ITGALKMT2A | |
| SCHEMBL5830523 | 0.72 | ITGB2 (0.65) | ITGB2ICAM1ITGALKMT2A | |
| SCHEMBL5829934 | 0.71 | EPHX2 (0.40) | PDE7AKMT2A | |
| SCHEMBL6196672 | 0.70 | ITGB2 (0.45) | ITGB2ICAM1ITGAL | |
| SCHEMBL5830364 | 0.69 | PDE7A (0.38) | PDE7AKMT2A | |
| SCHEMBL5829927 | 0.67 | ITGB2 (0.68) | ITGB2ICAM1ITGALKMT2A | |
| SCHEMBL6494066 | 0.67 | AKR1C3 (0.40) | PDE7AKMT2A | |
| SCHEMBL5830329 | 0.67 | ITGB2 (0.70) | ITGB2ICAM1ITGALKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878700-B1 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds | ABBOTT LABORATORIES (US) | 2005-04-12 | — | — | US | disclosed |
| US-6867203-B2 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds | ABBOTT LABORATORIES (US) | 2005-03-15 | — | — | US | disclosed |
| US-20040116518-A1 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds | ABBOTT LABORATORIES | 2004-06-17 | — | — | US | disclosed |