Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 9/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | INSR | P06213 | 1/20 | 0.57 |
| ▸ | MET | P08581 | 1/20 | 0.57 |
| ▸ | CDK2 | P24941 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 1/20 | 0.57 |
| ▸ | TEK | Q02763 | 1/20 | 0.57 |
| ▸ | AURKA | O14965 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6312556 | 0.90 | IGF1R (0.69) | IGF1RNPC1RAB9AEGFRINSR | |
| SCHEMBL6311579 | 0.80 | AURKA (0.73) | IGF1RNPC1RAB9AEGFRINSR | |
| SCHEMBL25881301 | 0.79 | MAP3K5 (0.66) | KDR | |
| SCHEMBL30512115 | 0.79 | MAP3K5 (0.66) | KDR | |
| SCHEMBL6319730 | 0.79 | IGF1R (0.71) | IGF1RNPC1RAB9AEGFRINSR | |
| SCHEMBL4874875 | 0.78 | NPC1 (0.56) | NPC1RAB9AAURKA | |
| SCHEMBL6642791 | 0.77 | IGF1R (0.71) | IGF1RNPC1RAB9AEGFRINSR | |
| SCHEMBL27846061 | 0.76 | NPC1 (0.54) | NPC1RAB9AMETKDR | |
| SCHEMBL2299253 | 0.76 | SCN9A (0.57) | NPC1RAB9AKDRAURKA | |
| SCHEMBL6312944 | 0.75 | IGF1R (0.67) | IGF1REGFRINSRMETCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6939874-B2 | Substituted pyrimidinyl derivatives and methods of use | AMGEN INC. (US) | 2005-09-06 | — | — | US | disclosed |