Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 10/20 | 0.73 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.73 |
| ▸ | IGF1R | P08069 | 8/20 | 0.67 |
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
| ▸ | INSR | P06213 | 1/20 | 0.59 |
| ▸ | MET | P08581 | 1/20 | 0.59 |
| ▸ | CDK2 | P24941 | 1/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.59 |
| ▸ | TEK | Q02763 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24496887 | 0.87 | NPC1 (0.59) | AURKAAURKBIGF1RKDRNPC1 | |
| SCHEMBL6314215 | 0.85 | IGF1R (0.56) | AURKAAURKBIGF1REGFRINSR | |
| Hydrochloric Acid SCHEMBL15487562 | 0.84 | AURKA (0.97) | AURKAAURKBCDK2NPC1RAB9A | |
| SCHEMBL6312556 | 0.81 | IGF1R (0.69) | AURKAIGF1REGFRINSRMET | |
| SCHEMBL6320480 | 0.81 | IGF1R (0.69) | AURKAAURKBIGF1REGFRINSR | |
| SCHEMBL1703678 | 0.81 | MGAM (0.56) | IGF1RKDRNPC1RAB9AMAPK8 | |
| SCHEMBL3300205 | 0.80 | AURKA (0.86) | AURKAAURKBNPC1RAB9AMAPK8 | |
| SCHEMBL6313422 | 0.80 | IGF1R (0.60) | AURKAAURKBIGF1REGFRINSR | |
| SCHEMBL6311161 | 0.80 | IGF1R (0.66) | AURKAIGF1REGFRINSRMET | |
| SCHEMBL590102 | 0.79 | IGF1R (0.52) | AURKAAURKBIGF1REGFRINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6939874-B2 | Substituted pyrimidinyl derivatives and methods of use | AMGEN INC. (US) | 2005-09-06 | — | — | US | disclosed |