Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 13/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 13/20 | 0.81 |
| ▸ | MAPT | P10636 | 6/20 | 0.81 |
| ▸ | RAB9A | P51151 | 2/20 | 0.81 |
| ▸ | NPC1 | O15118 | 1/20 | 0.81 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.81 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.72 |
| ▸ | CRHBP | P24387 | 2/20 | 0.70 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.70 |
| ▸ | HTT | P42858 | 6/20 | 0.63 |
| ▸ | LMNA | P02545 | 6/20 | 0.63 |
| ▸ | USP2 | O75604 | 4/20 | 0.63 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.60 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.60 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7732734 | 0.89 | MEN1 (1.00) | MEN1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL28198224 | 0.87 | MEN1 (0.86) | MEN1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL20936540 | 0.85 | MEN1 (0.71) | MEN1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL19886992 | 0.85 | MEN1 (0.71) | MEN1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL23009270 | 0.84 | MEN1 (0.78) | MEN1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL7709609 | 0.84 | KMT2A (0.69) | MEN1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL29655588 | 0.84 | MEN1 (0.77) | MEN1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL28739194 | 0.84 | MEN1 (0.77) | MEN1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL19886991 | 0.84 | MEN1 (0.69) | MEN1KMT2AMAPTRAB9ANPC1 | |
| SCHEMBL19327047 | 0.83 | MEN1 (0.80) | MEN1KMT2AMAPTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140336178-A1 | COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES | THE GENERAL HOSPITAL CORPORATION (US) | 2014-11-13 | — | — | US | disclosed |
| US-20140336178-A1 | COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES | THE GENERAL HOSPITAL CORPORATION (US) | 2014-11-13 | — | — | US | disclosed |
| US-20140336178-A1 | COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES | THE GENERAL HOSPITAL CORPORATION (US) | 2014-11-13 | — | — | US | disclosed |
| US-20130203733-A1 | COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-08-08 | — | — | US | disclosed |
| US-20130203733-A1 | COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-08-08 | — | — | US | disclosed |
| US-20130203733-A1 | COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-08-08 | — | — | US | disclosed |
| US-8404747-B2 | Compositions and methods for modulating interaction between polypeptides | THE GENERAL HOSPITAL CORPORATION (US) | 2013-03-26 | — | — | US | disclosed |
| US-8404747-B2 | Compositions and methods for modulating interaction between polypeptides | THE GENERAL HOSPITAL CORPORATION (US) | 2013-03-26 | — | — | US | disclosed |
| US-8404747-B2 | Compositions and methods for modulating interaction between polypeptides | THE GENERAL HOSPITAL CORPORATION (US) | 2013-03-26 | — | — | US | disclosed |
| US-20050239833-A1 | Compositions and methods for modulating interaction between polypeptides | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2005-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050239833-A1 | Compositions and methods for modulating interaction between polypeptides | IAPP, SERPINA6, SERPINA2 | MEN1 1736/4885KMT2A 4744/4885MAPT 2215/4885 |
| US-20130203733-A1 | COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES | IAPP, SERPINA6, SERPINA2 | MEN1 1736/4885KMT2A 4744/4885MAPT 2215/4885 |
| US-20140336178-A1 | COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES | IAPP, SERPINA6, SERPINA2 | MEN1 1736/4885KMT2A 4744/4885MAPT 2215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.