Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.65 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9094185 | 0.81 | GRM5 (0.65) | GRM5HAO1FFAR1ACACBPDE10A | |
| SCHEMBL30278513 | 0.80 | GRM5 (0.68) | GRM5HAO1ALOX5ACACBPDE10A | |
| SCHEMBL6311975 | 0.79 | GRM5 (1.00) | GRM5HAO1ACACBPDE10A | |
| SCHEMBL30469481 | 0.76 | GRM5 (0.69) | GRM5FFAR1 | |
| SCHEMBL30469478 | 0.76 | GRM5 (0.69) | GRM5FFAR1 | |
| SCHEMBL4562089 | 0.76 | GRM5 (0.69) | GRM5FFAR1 | |
| SCHEMBL9094022 | 0.76 | GRM5 (0.62) | GRM5HAO1ACACB | |
| SCHEMBL9092851 | 0.75 | GRM5 (0.56) | GRM5HAO1FFAR1 | |
| SCHEMBL15870993 | 0.74 | GRM5 (0.68) | GRM5HAO1ACACBPDE10A | |
| SCHEMBL30278486 | 0.74 | GRM5 (0.55) | GRM5HAO1FFAR1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6956049-B1 | Methods of modulating processes mediated by excitatory amino acid receptors | MERCK & CO., INC. (US) | 2005-10-18 | — | — | US | disclosed |
| EP-1214303-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | Merck & Co., Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001016121-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | MERCK & CO., INC. (US) | 2001-03-08 | — | — | WO | disclosed |